Most people will eventually upgrade to Windows 8, and today you can do so on the cheap. Grab the pro upgrade version on the cheap for $55 today from eBay. The eventual update from this to 8.1 will be free, in case there was any confusion there. [eBay]
Source: http://gizmodo.com/dealzmodo-windows-8-upgrade-dual-monitors-bamboo-sty-883892975
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NEW YORK (AP) ? Put Salman Rushdie, Martin Amis and Ian McEwan on a stage and expect a night of high art and school boy humor, of reading, writing and Christopher Hitchens.
And hysterical sex.
The three literary stars, all in their 60s and friends for more than half their lives, appeared together Monday night at the 92nd Street Y on Manhattan's Upper East Side. Amis and McEwan were there to read from their latest novels, both now out in paperback. Rushdie handled the introductions and the question and answer period that followed the readings.
They dressed for style and for leisure ? jackets, no ties ? and exchanged compliments, curse words and winks to the past. Rushdie mentioned an old game they liked to play, taking titles with the word "love" in them and substituting "hysterical sex," as in "Hysterical Sex Is a Many-Splendored Thing" or "Stop! In the Name of Hysterical Sex." Rushdie also made jokes about the Booker Prize (Rushdie and McEwan have won it; Amis has not) and about Amis' legacy as one of Britain's great angry young men, "ruining and disturbing" his country's fiction, as the old guard used to complain.
Amis read from a few sections of "Lionel Asbo," his dystopian take on 21st century Britain, and McEwan followed with a long passage from "Sweet Tooth," a spy novel and literary excursion. The audience questions, submitted on index cards, ranged from writerly matters such as the role of unreliable narrators in fiction (the distinguished gentlemen were all for unreliable narrators) to an incident back in the day when McEwan supposedly met a woman and immediately, crudely propositioned her.
His encounter was "not successful," McEwan assured the audience, and he "never tried that again."
Amis, a most accomplished womanizer in his time, added with a smirk: "I never did anything like that."
At the start, Rushdie had referred to a "missing fourth person," their departed friend Hitchens, who died of cancer in 2011. During the question and answer session, Rushdie noted that several cards filled out by audience members asked about the indomitable essayist and commentator and how the writers thought he would be remembered.
Amis observed that while Hitchens was known for his political commentary, he believed that Hitchens would endure as a "literary phenomenon," if only because Hitchens' politics were so "eccentric." (Hitchens was the rare author to have admiring words for both Karl Marx and the Iraq War). McEwan called Hitchens a "fantastic speaker" and "amazing in the art of conversation," and remembered how he spent his dying hours determined to complete a 3,000 word essay on the author G.K. Chesterton.
"That's what's so painful," McEwan said of Hitchens, adding that such a life and "combination of genes" were unlikely to be seen again.
Final question: Given the chance, which of their books would the writers like to change?
Amis said he wouldn't have minded another week to work on the novel "Time's Arrow," but otherwise disparaged the idea of revising old work. McEwan confessed that his first published book, the 1975 story collection "First Love, Last Rites," suffered from a love affair with commas. The author has been influenced, much too influenced, by the novels of Samuel Beckett and had fallen for the idea of using commas instead of periods to end sentences.
At the time, McEwan thought he had pulled off a triumph of "cunning," he explained.
"Now, it seems like the opposite of cunning."
Source: http://news.yahoo.com/amis-rushdie-mcewan-appear-together-ny-062151120.html
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"In the last two months, half the folks I sold homes to were young entrepreneurial types ? and they were all buying homes for over a million dollars," Washington D.C.'s Michael Rankin of TTR Sotheby's International Realty tells WSJ. He says those kinds of buyers didn't exist a few years ago.?
Rankin and other real estate professionals are seeing more clients skipping starter homes and condos altogether for sprawling houses. The tech boom is largely to thank. "Brokers say many of the young buyers today have made money during the IPOs of technology companies such as Facebook, Google, LinkedIn, or they have profited by starting their own companies," Blum writes. She cites one Facebook employee who moved from a rented 800-square-foot apartment to a $7 million 9,000 square-foot-home. A former Facebooker, Rick Armbruso, who is now 33, purchased a $1.2 million, 2,000-square foot home 2.5 years ago.
For those who aren't independently wealthy, parents are stepping up to the plate. A luxury broker in Los Angeles tells WSJ she's seen "more parents buy home for their children in the last year than in [her] whole career."
The reason: There's a generation of wealth that didn't exist before in America. Baby Boomers made more money as a whole than their parents.
"For the first time since the pre-Depression, Gatsby era, we have a generation of kids whose parents made a great deal of money and are giving a great deal of it to their children," Harrson Group's Jim Taylor tells WSJ. He recently conducted a study about wealth in America with American Express Publishing. "Prior to this, very few families had money through inheritance. There is a living wealth transfer currently taking place that this country hasn't seen in decades."
Source: http://www.businessinsider.com/millenials-invest-in-real-estate-2013-7
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For three decades, most of us have interacted with computers in exactly the same way: We point with a mouse (or a finger!), click, and watch the screen. In one way, it's the most outdated element of human computer interaction around. But in another, it's the thing that's shaped every operating system and device designed since its invention. We're starting to leave it behind, though. Here's what's coming next.
Source: http://gizmodo.com/what-comes-after-click-a-crash-course-in-tangible-user-815532137
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NEW YORK (AP) ? Netflix is going to start running original television series from Dreamworks Animation.
Financial terms were not disclosed.
Netflix Inc. says the multi-year agreement is its biggest deal ever for original first-run content and includes more than 300 hours of new programming. It expands on an existing relationship between the companies.
For Dreamworks, the transaction announced Monday is part of a major initiative to expand its television production and distribution worldwide.
Netflix has been adding original programming to its roster of movies, and debuted the original series "House of Cards" on Feb. 1. It has also increased its focus on children's programming in a move seen as taking a different tack than traditional premium pay TV channels such as HBO, Starz and Showtime, whose original shows are tailored more to adults.
In December Netflix announced it will offer Disney movies, starting with films released in 2016. It declined to make a similar deal for the rights to Sony movies starting in 2016, which was kept by Starz.
The new Dreamworks shows will be inspired by characters from its hit franchises like "Shrek" and "Kung Fu Panda" and upcoming feature films as well as the Classic Media library that Dreamworks Animation SKG Inc. bought last year. The television shows will be commercial free.
The first series is expected to begin airing in 2014 and will be shown in the 40 countries in which Netflix operates.
In February the companies announced their first ever Netflix original series for kids based on the film "Turbo" that is coming out in movie theaters next month. The original series, called "Turbo F.A.S.T.," will be shown starting in December.
Next year Netflix customers in the U.S. and Latin America will also have access to some of Dreamworks' newest films, including "The Croods" and "Turbo."
Netflix shares rose $12.29, or 5.7 percent, to $226.28 in morning trading. Dreamworks shares rose $1.69, or 7.4 percent, to $24.50.
Source: http://news.yahoo.com/netflix-run-original-tv-series-dreamworks-103032177.html
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A team of archaeologists from Australia has found an ancient city buried for more than 1,000 years beneath Cambodia's soupy jungles.
Tourists wait to see a sunrise at the famed Angkor Wat temple in Siem Reap province, Cambodia.
Heng Sinith/AP
EnlargeIf at seems at times that our globe is already thoroughly mapped and explored, all its corridors charted and its mysteries explained, then the latest news out of Southeast Asia is solacing ? there are, it seems, still lost worlds to be discovered, combed out from beneath a millennium of accumulated jungle in remote Cambodia.
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A team of archaeologists from Australia has found an ancient city that has for more than 1,000 years escaped detection ? not even looters had found the mysterious place, buried in Cambodia?s otherwise heavily trafficked Siem Reap province, which sees about a million tourists each year, Australia's The Age reported.
Known as Mahendraparvata, the lost world is some 1,200-years old, about 350 years older than the Angkor Wat temple complex, also in Siem Reap. Like Angkor, it was part of the Hindu-Buddhist Khmer Empire that from about 800 A.D. to 1400 A.D. ruled?Southeast Asia, using slave labor to construct opulent, arrestingly beautiful stone temples.
Damian Evans, director of the University of Sydney's archaeological research center in Cambodia, and a small group of colleagues working in Cambodia?s northwestern corridor first mapped the area, Cambodia?s Phnom Kulen mountain, using airborne Lidar, a remote-sensing technology that uses lasers. The Lidar data revealed structures hidden beneath Technicolor green of rural Cambodia?s thick jungles, giving scientists the basic outline of the almost mythical place ??as well as the wish to know more.
Weeks later, guided by an ex-Khmer Rogue soldier familiar with the terrain, the team hacked their way to the remnants of this once-booming cosmopolis:?abandoned, overgrown temples, as well as evidence of roads and canals.
Scientists are unsure why Mahendraparyata was abandoned ??possibly, the area had suffered too much?environmental degradation to support the empire?s burgeoning population. Turned over to time, the royal city was worked to rubble as a millennium of industrious vegetation and monsoon rains did their worst. The mountain itself, once home to the peak of Cambodian culture, would go on to witness one of its worst moments, becoming a Khmer Rouge stronghold in the 1970s.
Throughout all that, the mountain has remained a spiritual place, host to tens of thousands of pilgrims each year.
Source: http://rss.csmonitor.com/~r/feeds/csm/~3/P7di9VT_xnw/In-Cambodia-s-jungles-a-lost-world-is-found
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Eddie Redmayne poses on the court at the Rally Against Cancer Charity Tennis Match during the AEGON Championships at Queens Club on Sunday (June 16) in London, England.
The 31-year-old actor was joined by Virgin Group founder Richard Branson.
PHOTOS: Check out the latest pics of Eddie Redmayne
The month before, Eddie donned a tuxedo at the 2013 Met Gala held at the Metropolitan Museum of Art in New York City.
Eddie?s next role is in the upcoming film Jupiter Ascending, set to be released next summer!
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Source: http://www.justjared.com/2013/06/16/eddie-redmayne-rally-against-cancer-charity-tennis-match/
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Jason Day, of Australia, acknowledges the gallery after putting on the 17th hole during the fourth round of the U.S. Open golf tournament at Merion Golf Club, Sunday, June 16, 2013, in Ardmore, Pa. (AP Photo/Gene J. Puskar)
Jason Day, of Australia, acknowledges the gallery after putting on the 17th hole during the fourth round of the U.S. Open golf tournament at Merion Golf Club, Sunday, June 16, 2013, in Ardmore, Pa. (AP Photo/Gene J. Puskar)
Jason Day, of Australia, reacts after a putt on the 18th hole during the fourth round of the U.S. Open golf tournament at Merion Golf Club, Sunday, June 16, 2013, in Ardmore, Pa. (AP Photo/Morry Gash)
Jason Day, of Australia, reacts after a putt on the 15th hole during the fourth round of the U.S. Open golf tournament at Merion Golf Club, Sunday, June 16, 2013, in Ardmore, Pa. (AP Photo/Darron Cummings)
Jason Day, of Australia, reacts to a missed putt on the 13th hole during the fourth round of the U.S. Open golf tournament at Merion Golf Club, Sunday, June 16, 2013, in Ardmore, Pa. (AP Photo/Morry Gash)
ARDMORE, Pa. (AP) ? Third place at the Masters. Tied for second at the U.S. Open.
And that's just this year.
Jason Day's too young to get saddled with that dreaded Best Player Never To Win a Major label, so he might as well go ahead and win one.
"As long as I keep knocking on the door," he said Sunday, "I think I'll win a major here soon."
It sure looks inevitable after watching him this week at Merion Golf Club. Rounds of 70, 74, 68 and 71 can be worn liked a badge of honor at a championship in which the winning score was Justin Rose's 1-over 281. Day finished two shots back, tied with Phil Mickelson.
"At the start of the week everyone thought we were going to rip it up," Day said. "But I just knew that somewhere around even par was going to win it, and I just had to stick in there. So I was very patient with myself and happy with how I handled myself, and now I just got to keep giving myself shots at majors."
The 25-year-old Day has played in five majors. He's finished out of the top 10 only once.
The Australian debuted with a tie for 60th at the 2010 British Open. Since then, his record is the envy of many of his colleagues: tied for 10th at the 2010 PGA Championship, tied for second behind champion Charl Schwartzel at the 2011 Masters, outright second behind Rory McIlroy at Congressional in 2011.
This year, he's the only player to finish in the top 10 in both majors.
Day spent Sunday hovering near the top, unable to break through because he kept canceling himself out. Birdie at No. 4, bogey at No. 5. Birdie at No. 10, bogey at No. 11. He was one off the lead when he got to 18, but he put his approach in the bunker and missed a 5-footer for par.
No shame there. No one birdied the finishing hole over the final two rounds. It was the shortest major championship course in nine years, but the scores were typical U.S. Open.
"I think that every club in the bag got a workout this week," he said. "So I think that it would be sad for it not to come back (here) to a U.S. Open."
His best shot came right after his worst one. He went from rough to creek at No. 11, then nearly put his next shot into the creek as well. But he holed out from the nasty rough for bogey.
From there, he had near misses, when he wasn't scrambling: "Nearly made the birdie on 13. ... Nearly holed a good putt on 15. ... Had two good saves on 16 and 17."
Too many near misses to win. He probably knew it when he tossed his club after the miss at 13. Or when he put both hands over his head after the miss at 15.
All of which means he's still 14 victories behind Tiger Woods when it comes to majors. Day ended his remarks by referencing the world's No. 1 player.
"You got to understand that, late Sunday of a U.S. Open ? and U.S. Open courses are very hard ? you can't do anything but kind of grind (it) out," Day said. "Like Tiger said at the start of the week, you just got to keep grinding those 10 footers and just grind away. So I was happy with how I played."
___
Follow Joseph White on Twitter: http://twitter.com/JGWhiteAP
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LONDON (Reuters) - A smiling Prince Philip, the 92-year-old husband of Britain's Queen Elizabeth, left hospital after 11 days on Monday, slightly earlier than expected, following an operation on his abdomen. Looking sprightly and in good spirits, the prince walked unaided out of the London Clinic, shaking hands with the staff and waving to onlookers outside, before getting into his car to be driven to Windsor Castle, west of London. ...
Source: http://news.yahoo.com/roche-drug-approved-japan-treatment-brain-cancer-053905868.html
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The landslide election of the only moderate candidate in the Iranian presidential contest stunned the Islamic Republic?s hardline establishment, which had taken great pains to tilt the field of candidates toward conservatives sycophantic to Supreme Leader Ali Khamenei. By collecting more than half of the vote in the first round of balloting, reformist cleric Hassan Rowhani was borne into Iran?s highest elective office by a broad public desire to correct the insular, right-wing trajectory of Iranian political discourse and bring the country out of the severe economic and diplomatic isolation imposed by world powers intent on Iran?s nuclear program.
Rowhani?s election, announced by the Interior Ministry, recalled the surprise 1997 win of Mohammad Khatami. Khatami?s victory transformed the political landscape of the theocratic state established after the 1979 revolution overthrew the U.S.-backed monarchy of Shah Reza Pahlavi. But the presidential election some celebrating Iranians had in mind Saturday was the last one, the 2009 ballot that was widely seen as stolen from reformist candidate Mirhossein Moussavi, resulting in weeks of violent protests and mass arrests. Chants of ?Moussavi, Moussavi, I got back your vote? and ?Moussavi, Moussavi, congratulations on your victory,? were heard outside Rowhani?s campaign headquarters in downtown Tehran, according to Reuters. The impact on Iran?s nuclear program, and stalled negotiations intended to assuage international concerns about its intents, was far from clear. ?But in a field of candidates winnowed from more than 100 to just eight by a conservative clerical body known as the Guardian Council ? and then reduced to six by strategic withdrawals ? Rowhani was the only candidate who called for ?rationality and moderation? after eight years of President Mahmoud Ahmadinejad, the right-wing populist Khamenei twice supported in hopes of bringing the country?s elected and unelected spheres into harmony. Instead, Ahmadinejad challenged the Leader during his second term, while the world at large condemned Iran both for Ahmadinejad?s reckless rhetoric ? he repeatedly denied the Holocaust? ? and the regime?s defiant refusal to reassure the UN?s International Atomic Energy Agency that its nuclear program is intended only for peaceful purposes.
?What I truly wish is for moderation to return to the country,? Rowhani told the reformist daily Sharq in a June 12 interview. ? This is my only wish. Extremism pains me greatly. We have suffered many blows as a result of extremism.?
Rowhani, 64, was Iran?s chief nuclear negotiator when Khatami?s government ? with the assent of Khamenei ? agreed to suspend uranium enrichment to reassure a worried world after the clandestine program was discovered in 2002. After enrichment resumed in 2005, he boasted that Iran had used negotiations to stall for time while installing additional centrifuges in its underground plant.
He campaigned on a program of ending the nuclear stand-off and freeing Iran?s economy of the crippling sanctions that have cost the country billions in lost oil revenue and foreign investment, while sharply reducing the value of its currency. ?I said it is good for centrifuges to operate, but it is also important that the country operates as well and the wheels of industry are turning,? Rowhani said in one television interview. The approach was at odds with the defiance preached by Khamenei?s preferred candidate, current nuclear negotiator Saeed Jalili. Though detailed results were not immediately available, all preliminary counts had second place going to Tehran?s mayor Mohammad Qalibaf. A spokesman for Israel?s government noted in a statement that ?Iran?s nuclear program has so far been determined by Khamenei, not by Iran?s President. After the elections, Iran will continue to be judged by its actions, in the nuclear sphere as well as on the issue of terror.?
Rowhani also spoke of ?minimizing? the longstanding hostility between Iran and the United States, which broke off diplomatic relations with Tehran after the takeover of its embassy there, engendering an enmity nurtured by both sides ever since. The approach is in line with reformist doctrine ? Khatami reached out repeatedly to America, calling for ?dialogue? ? but meaningful rapprochement has been thwarted by Khamenei, who remains deeply distrustful of Washington.
His own frustration in the job once led Khatami to declare that Iran?s president has less power than an average citizen. In fact, the president appoints the cabinet and provincial governors. But the elected office stands below an expansive apparatus of unelected offices and panels, topped by Khamenei, who wields direct control over the the Iranian Revolutionary Guard Corps, the national security apparatus and even much of Iran?s economy, two-thirds of which is directly controlled by the regime.
Little in the normally opaque, complex ruling apparatus is as clear and powerful as the election result, however.? After the riots and foment of 2009, Khamenei was clearly intent on restoring the credibility of the polls, and expressed satisfaction with the campaign as voting was underway Friday.? Turnout was reported in the vicinity of 70 percent. ?In 2009 was same excitement but w/ insults; this election has no disrespect,? Khamenei?s office Tweeted. ?It?s valuable that we?ve progressed so much in 4 years.?
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<em>Series premieres Wed., May 1 at 8:30 p.m. ET.</em> <strong>What To Know</strong>: Starring J.K. Simmons and Kyle Bornheimer, "Family Tools" centers on a guy who returns home to take over his dad's hardware business when he finds himself jobless.
<em>Season 10 premieres Wed., May 1 at 9 p.m. ET.</em> <strong> What To Know</strong>: This season there will be a "Breaking Bad" themed episode and the crew will tackle myths such as "Are women better than men at multitasking?" and "Which is more sanitary: drying your hands with a hand dryer or a hand towel?"
<em>Series premieres Wed., May 1 at 10 p.m. ET.</em> <strong>What To Know</strong>: Hosted by Kal Penn, this reality competition show will give contestants 30 minutes to solve a daunting engineering challenge.
<em>Series premieres Thurs., May 2 at 10:30 p.m. ET.</em> <strong>What To Know:</strong> The series follows Zach (Bo Burnham), who hires a camera crew to film him throughout his daily life as a part of his quest to become an overnight celebrity ? even though he possesses no real talent. From Zach?s attempts to become a celebrity chef or a ring-tone recording artist to purposefully going missing, he?ll try any avenue to get noticed and stop at nothing until he reaches fame.
<em>Series premieres Thurs., May 2 at 10 p.m. ET.</em> <strong>What To Know:</strong> For the legions who can't say goodbye to "Jersey Shore" just yet, the legacy continues as we follow GTLer Vinny into his sure-to-be-scintillating home life. The premise has random "celebrities" dropping by his house for impromptu interviews -- and Vinny going to visit their homes, too.
<em>Series premieres Mon., May 6 at 10 p.m. ET.</em> <strong>What To Know:</strong> Bravo's new eight-episode docu-series follows four newlywed couples and their most personal moments, from their wedding day to their first anniversary. There's bi-coastal Christian couple Kimberly and Alaska; domestic partners Jeff and Blair, who are 16 years apart; Indian pop star Tina and her modeled-turned-tech-geek husband Tarz; and suburbanites Kathryn and John.
<em>Season 2 premieres Wed., May 8 at 10 p.m. ET.</em> <strong>Where We Left Off:</strong> Because we're all so fascinated by real estate that we could never realistically afford, this show is returning for a second season. C'mon, it's fun to live vicariously.
<em>Season 6 premieres Thurs., May 9 at 8 p.m. ET.</em> <strong>Where We Left Off:</strong> With Season 5 episodes titled "Hillbilly Wipeout," "Gorillas In Our Midst" and "Hotties vs. Nerds 2.0," there can only be more magic in store for Season 6. Viewers of all stripes love watching people hurt themselves in new and remarkable ways.
<em>Series premieres Sun., May 12 at 10:30 p.m. ET.</em> <strong>What To Know:</strong> "Bridesmaids" funnyman Chris O'Dowd stars in Christopher Guest's ("Best in Show") new documentary-style series about a hapless thirtysomething trying to find meaning in his life by tracing his heritage.
<em>Season 4 premieres Sun., May 12 at 9 p.m. ET.</em> <strong>Where We Left Off:</strong> We were hoping that those nails and that hair would be around for another season -- and our wish came true! Theresa Caputo is back, communicating with the dead, for at least another 30 episodes.
<em>Season 2 premieres Sun., May 12 at10 p.m. ET .</em> <strong>Where We Left Off:</strong> Speculation and accusations about the show?s ?reality? aside, ?Breaking Amish? was a hit for TLC. Now, the five Amish and Mennonite rebels, who moved to New York City in the show?s first season, are headed south to Florida ... but trouble seems to follow them wherever they go.
<em>Season 2 premieres Thurs., May 9 at 10 p.m. ET.</em> <strong>Where We Left Off: </strong> In Season 1, we met the owners and employees of JJK Security in small-town Ringgold, Georgia, and Season 2 will offer more insight into the unscripted lives of this unusual group, including Dennis' ongoing journey in his gender transition from female to male.
<em>Season 10 premieres Tues., May 14 at 8 p.m. ET. </em> <strong>Where We Left Off:</strong> After a season of intense competition, Eliana Girard and Chehon Wespi-Tschopp took home first place wins, both for ballet, while Tiffany Maher was the female runner-up for jazz and Cyrus Spencer was the male runner-up for popping/animation.
<em>Series premieres Thurs., May 23 at 9 p.m. ET.</em> <strong>What To Know:</strong> Billed as a unique, original approach to the typical cop drama, "Motive" operates backwards. Each episode starts off showing the victim, and then works its way towards finding the perpetrator and his/her motivations by the end of the episode.
<em>Series premieres Mon., May 20 at 8:30 p.m. ET.</em> <strong>What To Know: </strong> The Fox comedy centers on estranged siblings Henry (Scott Foley), Chloe (Becki Newton) and Jimmy (T.J. Miller) as they attempt to "rediscover their lives" with the money their father left them.
<em>Season 4 premieres Wed., May 22 at 8 p.m. ET.</em> <strong>Where We Left Off:</strong> The home cook competition crowned its third consecutive female winner last season, Christine Ha. Cool fact: She is legally blind. No telling what twists they'll have this season.
<em>Season 4 premieres Thurs., May 23 at 10 p.m. ET.</em> <strong>Where We Left Off:</strong> The last time we saw the cops at 15 Division, they were all in the midst of making some serious decisions about their lives -- including career calls, a possible transfer and, for Andy, a major emotional choice.
<em>Series premieres Thurs., May 23 at 8 p.m. ET.</em> <strong>What To Know:</strong> After a near-death experience, Beth (Anne Heche) is revived only to realize she now has a direct line to God. Of course, her husband Tom (Michael Landes) is skeptical and dismissive -- but when inexplicable things begin to happen, everyone?s beliefs are tested.
<em>Season 9 premieres Mon., May 20 at 9 p.m ET.</em> <strong>Where We Left Off: </strong> Emily Maynard of North Carolina thought she'd finally found love in Jef Holm, but after only being engaged for a short time, they broke up. Here's to hoping "Bachelor" contestant Desiree Hartsock has better luck!
<em>Season 4 premieres Mon., May 26 at 12:01 a.m. PT.</em> <strong>Where We Left Off:</strong> The Bluths are finally back, but there's no telling where and how we'll actually find them. One thing we do know: Each of the nine main characters will have their own episode in this season's 15-episode order, chronicling what they've been up to the last seven years. Some may cross over, but they'll all be complementary -- and they're all meant to set up an eventual "AD" movie. Considering the season will all be available the day it premieres, it sounds pretty perfect for a marathon viewing.
<em>Season 4 premieres Mon., May 27 at 9 p.m. ET.</em> <strong>Where We Left Off:</strong> In the Season 3 finale, Jim (Matt Passmore) proposed to Callie (Kiele Sanchez), even though she passed her board exam and may move to Atlanta. But she didn't respond yet ...
<em>Season 2 premieres Mon., May 27 at 10 p.m. ET.</em> <strong>Where We Left Off:</strong> Did Walt Longmire murder his wife's killer? Season 1 saw flashbacks of the Sheriff of Absaroka County, Wyoming, that would support the theory, but when the FBI asked him in the Season 1 finale, he simply said, "No."
<em>Season 3 premieres Tues., May 28 at 8 p.m. ET.</em> <strong>What To Know:</strong> As in the seasons before it, "Extreme Makeover: Weight Loss Edition" will center on a group of people losing large amounts of weight over the course of a year through diet and exercise.
<em>Series premieres Tues., May 28 at 10 p.m. ET.</em> <strong>What To Know</strong>: The six-part series takes viewers behind the scenes of the Brooklyn District Attorney's office. ADA Kathleen Collins (pictured) is just one of the profiled attorneys. "When you?re on trial, there?s never a day that you really go home and don?t feel stressed," she said.
<em>Series premieres Wed., May 29 at 8 p.m. ET.</em> <strong>What To Know:</strong> Based on a popular British reality competition, this new Jeff Foxworthy-hosted show features 10 home cooks vying for the title of best amateur baker in America, as well as a contract to publish their own cookbook and a $250,000 grand prize. Not bad for a couple of pies work, huh?
<em>Season 3 premieres Wed., May 29 at 8 p.m. ET.</em> <strong>Where We Left Off:</strong> Joe married Russian businesswoman Elena, but then she received a call that prompted her to fly back to Russia to testify for one of her innocent colleagues. The Season 2 finale ended with Mel -- who officiated the wedding -- and Joe toasting to the next "Mrs. Longo," wherever she may be.
<em>Season 2 premieres Wed., March 29 at 8:30 p.m. ET. </em> <strong>Where We Left Off:</strong> Ben and Riley's friend Katie faced some major drama when they found themselves in bed together after a night of partying. The only problem with their little tryst was that Katie was supposed to get married (to someone else) the next day. Luckily, they soon find out that nothing happened, and Riley and Ben share a romantic dance.
<em>Series premieres Wed., May 29 at 9 p.m. ET.</em> <strong>What To Know: </strong> The half-hour comedy clip show, hosted by "Baby Daddy" star Melissa Peterman, features the funniest, most outrageous and memorable dances caught on camera. The dancers from the top two clips of the week compete on stage for a chance to win $10,000.
<em>Season 3 premieres Sun., June 2 at 9 p.m. ET.</em> <strong>Where We Left Off:</strong> Season 2 ended with Rosie Larsen's Aunt Terry being arrested for her murder. Detectives Linden (Mireille Enos) and Holder (Joel Kinnaman) got a call about a new case, but Linden wanted no part of it. Season 3 picks up a year later, with Holder searching for a runaway girl and discovering a string of murders connected to one of Linden's old cases. Though Linden is no longer a detective, she inevitably gets pulled back in.
<em>Season 5 premieres Sun., June 2 at 8 p.m. ET.</em> <strong> Where We Left Off</strong>: The "Housewives" were fractured -- to say the least -- but the aftermath of Hurricane Sandy brings new beginnings for the first ladies of the Garden State. Of course things could certainly go sour yet again.
<em>Series premieres Sun., June 2 at 9 p.m. ET.</em> <strong>What To Know</strong>: The reality series follows six college-educated women from affluent areas of Long Island who are still living with their families.
<em>Season 8 premieres Sun., May 20 at 9 p.m. ET.</em> <strong>Where We Left Off:</strong> Kim and Kanye?s relationship was just breaking the Internet, and now we?ll see it all on screen -- including their baby drama. Khloe?s fertility issues continue, but new ?castmember? Brody Jenner -- Bruce?s son from a previous marriage who is no stranger to reality TV -- looks to be this season?s biggest diva.
<em>Series premieres Mon., June 3 at 10 p.m. ET.</em> <strong>What To Know:</strong> Soapy drama "Mistresses" stars Alyssa Milano, Yunjin Kim, Rochelle Aytes and Jes Macallan as four friends all struggling with different issues in their love lives, with men (including Jason George) and other women complicating matters. And as the title suggests, some of them are flirting with disaster and becoming mistresses themselves.
<em>Series premieres Mon., June 3 at 9 p.m. ET. </em> <strong>What To Know: </strong>This new one-hour drama from executive producer Jennifer Lopez follows a multi-ethnic, blended family, being raised by two working moms, as they welcome another troubled child into their home.
<em>Season 3 premieres Mon., June 3 at 10 p.m. ET.</em> <strong>Where We Left Off:</strong> At the end of last season, Allison broke up with Scott, Peter warned Isaac and Derek that a new pack made up entirely of Alpha werewolves was coming, and said Alphas trapped Boyd and Erica in the woods, leaving viewers uncertain of their fate. Season 3 will pick up four months later, and focus on the introduction of the Alpha pack and the havoc they wreak.
<em>Season 2 premieres Mon., June 3 at 10 p.m. ET.</em> <strong>Where We Left Off: </strong> Throughout Sesaon 1 we got to know Auti, Mia, Tiphany and Chelsie, four women living in Hollywood who also happen to all be in wheelchairs. Season 2 will follow the foursome's new loves and new adventures, including 21-year-old Chelsie's decision to move out of her parents' home.
<em>Season 8 premieres Tues., June 4 at 9 p.m. ET</em> <strong>Where We Left Off:</strong> Last season, traveling dog act Olate Dogs was crowned the winner. This year, a new crop of performers will compete for the $1 million prize. Spice Girl Mel B. and Heidi Klum join the judging panel with Howie Mandel and Howard Stern.
<em>Season 7 premieres Thursday, June 6 at 9 p.m. ET.</em> <strong>Where We Left Off:</strong> In an effort to get more information on Riley, Michael sent Bly to tail her to a meeting with the cartel kingpin, but a cartel member disguised as security blew up Bly's car, killing him and destroying the evidence they collected on Riley. Michael later incapacitated Riley and got her to agree to confess. Then, Fiona, Madeline, Sam and Jesse were released from their prison cells. Michael explained he "did what [he] had to do," but Fiona corrected him, saying, "You did what you wanted to do."
<em>"Graceland" premieres Thurs., June 6 at 10 p.m. ET.</em> <strong>What To Know:</strong> This cop drama, starring Daniel Sunjata and Aaron Tveit, follows a special group of law enforcement agents from the FBI, the DEA and U.S. Customs who all live under the same roof in sunny Southern California. Like frat guys (and girls), but with badges.
<em>Series premieres Thurs., June 6 at 8 p.m. ET.</em> <strong>What To Know:</strong> Dwayne "The Rock" Johnson is producing this competition series to test the strength, courage and integrity of a diverse group of nine individuals. Each week, the contestants will be challenged physically, mentally and morally as they try to prove that they truly deserve the title of "The Hero" and the life-changing grand prize that goes with it.
<em>Series premieres Thurs., June 6 at 9 p.m. ET.</em> <strong>What To Know:</strong> Contestants on this "Survivor"-esque reality show are dropped into the wilderness with only a bottle of water and a GPS device on a mission to find a briefcase filled with $100,000.
<em>Season 2 premieres Fri., June 7 at 10 p.m. ET.</em> <strong>Where We Left Off:</strong> According to series lead Rachel Nichols, Season 2 is all about responsibility. Kiera, Alec and even the terrorists at Liber8 all have to make intense choices that could change the very fabric of their worlds.
<em>Season 8 premieres Sun., June 30 at 9 p.m. ET.</em> <strong>Where We Left Off: </strong> Deb finally learned the truth about Dexter's dark secret, and took a page out of her step-brother's book in the shocking season finale. Can she live with what she did? And can Dexter escape the series without being brought to justice in this final season?
<em>Season 5 premieres Sat., June 8 at 10 p.m. ET.</em> <strong>Where We Left Off:</strong> Our favorite supernatural threesome is back from across the pond for their fifth and final season where they'll finally confront the Devil, once and for all. No biggie.
<em>Series premiere Sat., June 8 at 9 p.m. ET.</em> <strong>What To Know:</strong> The 12-episode British series follows the epic sea journey of the flawed hero Sinbad (Elliot Knight), who embarks on a quest to rid himself of a curse and embrace his destiny. Look for "Lost" alum Naveen Andrews as Lord Akbari.
<em>Series premieres Sat., June 8 at 10 p.m. ET.</em> <strong> What To Know</strong>: The 13-episode first season follows a team of animal experts and scientists that investigate paranormal events.
<em>Season 3 premieres Sun., June 9 at 10 p.m. ET.</em> <strong>Where We Left Off:</strong> Last season ended with the arrival of a new species of alien, and Anne became pregnant with Tom's child. Season 3 will explore whether the new alien is on the side of the humans or has another dark purpose in mind. We'll also learn what happened to Hal while he was unconscious, and what that might mean for the rebellion.
<em>Season 2 summer premiere Mon., June 10 at 8 p.m. ET.</em> <strong>Where We Left Off</strong>: "Switched At Birth" left on a big cliffhanger: Daphne struggled to keep the Carlton School for the Deaf open, John's campaign for office came to a startling halt and Emmett told Bay about Daphne and Noah's kiss.
<em>Season 2 premieres Mon., June 10 at 9 p.m. ET.</em> <strong>Where We Left Off</strong>: Rusty became a ward of the state to the delight of everybody, and Captain Raydor continued to gain the trust and respect of the Major Crimes unit.
<em>Series premieres Mon., June 10 at 10 p.m. ET.</em> <strong>What To Know:</strong> Based on author David Baldacci?s bestselling private eye series, Rebecca Romijn and Jon Tenney star as the titular former Secret Service agents now working as private investigators who aren?t always by-the-books.
<em>Season 4 premieres Tues., June 11 at 8 p.m. ET.</em> <strong>Where We Left Off:</strong> Red Coat, who looked a whole lot like Ali, saved Emily, Aria, Hanna and Mona from a fire, while Spencer looked on in shock. The first episode of Season 4 is titled "A Is For A-L-I-V-E" and <a href="http://www.eonline.com/news/394204/spoiler-chat-scoop-on-pretty-little-liars-once-upon-a-time-revolution-new-girl-and-more" target="_hplink">E! News reports that viewers will meet Marion, Toby's mother</a>, who was <a href="http://www.huffingtonpost.com/jaimie-etkin/pretty-little-liars-recap_b_2673316.html" target="_hplink">revealed to be dead in Season 3, Episode 18, "Dead To Me."</a> "All of the questions fans have will be answered," <a href="http://www.wetpaint.com/pretty-little-liars/articles/pretty-little-liars-star-sasha-pieterse-dishes-on-season-4-questions-will-be-answered-exclusive" target="_hplink">star Sasha Pieterse told Wetpaint Entertainment recently</a> of Season 4.
Source: http://www.huffingtonpost.com/2013/06/17/miss-usa-utah-create-education-better-video_n_3451896.html
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The premier of Man of Steel
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| Turquoise Thompson will compete in the 400 hurdles. (Jay L. Clendenin / Los Angeles Times / May 17, 2013) |
June 5, 2013, 10:16 a.m.
Nine UCLA athletes will compete in the NCAA track and field championships the next three days in Eugene, Ore.
On the men's side, the Bruins have Alec Faldermeyer (hammer), Dominic Giovannoni (decathlon), Marcus Nilsson (decathlon) and Julian Wruck (discus).
On the women?s side, Brea Buchanan (100-meter hurdles), Kylie Price (100, long jump), Tatum Souza (heptathlon), Ida Storm (hammer) and Turquoise Thompson (400 hurdles) will compete.
Follow the events live at http://pac-12.com/live/goducks/track-field.aspx.
ALSO:
Ohio State President Gordon Gee to retire July 1
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MLB to seek suspensions of Ryan Braun, Alex Rodriguez, report says
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June 5, 2013 ? A cheaper, more efficient technique for developing complex protein drugs from bacteria has been developed at the University of Sheffield.
Using the bacterium E. coli, researchers from the University's Faculty of Engineering showed it was possible to vastly increase the efficiency of the cells producing specifically modified proteins, as well as improve its performance and stability. The modification is present in over two-thirds of human therapeutic drugs on the market and involves the addition of specific sugar groups to the protein backbone, a process termed glycosylation.
Drugs based on proteins are increasingly important in modern medicine to tackle health problems including diabetes, cancer and arthritis.
Although simple proteins are traditionally made in microbial cells, these types of complex drugs are made using animal cells because they can make human-type glycosylations that will control its efficacy and stability in the body, and avoid immunogenic reactions in patients.
Using bacteria to make proteins for use as medicines could be a more cost effective alternative, since using animal cells is expensive. However, the efficiency of glycoprotein production in bacterial cells is still very poor, with yields often several thousand times lower than in animal cells.
Now, researchers in the Department of Chemical and Biological Engineering at the University of Sheffield, with collaboration from the University of Colorado, are using a technique called inverse metabolic engineering, that allows them to screen cells to identify strains that are likely to be the most efficient glycoprotein producers. Using this method, the team were able to produce seven times as much of the protein in laboratory tests.
The team then used mass spectrometry to characterise and accurately quantify the proteins being produced by the bacteria. This allowed them to pinpoint modifications that will enable them, ultimately, to improve the performance of the drug.
Professor Phil Wright, who led the research, said: "We believe that this technique will pave the way for pharmacologists to get the same protein yield from bacteria cells as they could from animal cells and also enable them to produce drugs from bacteria that have vastly improved focus and accuracy."
The team also tested the technique on antibody fragments with positive results, showing that their approach could work in different proteins.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/yRAe-uGCvjk/130605104428.htm
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LONDON (AP) ? The former chief executive of Rupert Murdoch's News International has pleaded not guilty to all charges related to phone hacking.
Rebekah Brooks entered pleas Wednesday at London's Southwark Crown Court along with almost a dozen other defendants in the phone hacking scandal that rocked Britain's political and media establishment.
The scandal erupted in 2011, after it was revealed that journalists at News International's now-shuttered News of the World tabloid routinely hacked into the voicemail messages of the rich, the powerful and other potential information sources.
The scandal rocked Britain's establishment and spawned a substantial police investigation and a host of official inquiries.
Source: http://news.yahoo.com/brooks-pleads-not-guilty-hacking-charges-103831225.html
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NEW YORK (AP) ? Robin Roberts will tell the story of her battle with a life-threatening illness in a new memoir.
Grand Central Publishing says the "Good Morning America" anchor will be writing the as-yet-untitled book for publication next April.
The publisher announced Wednesday that Roberts will write about her rare illness and her recovery, as well as the life lessons she continues to learn since her return to the "GMA" anchor desk.
The ABC News host underwent a bone marrow transplant in September to treat the blood and bone marrow disease. She was off work for five months before returning to the top-rated network morning show in February.
Her first book, "From the Heart: 7 Rules to Live By," was a New York Times best-seller in 2007.
Source: http://news.yahoo.com/gma-host-roberts-write-memoir-illness-131453439.html
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The results of a new research study could provide the impetus to improve or adopt a healthy lifestyle ? especially?for those with stressful jobs.
As reported in the CMAJ (Canadian Medical Association Journal), researchers discovered people with job stress and an unhealthy lifestyle are at higher risk of coronary artery disease than people who have job stress but lead healthy lifestyles.
Researchers studied the effect of a healthy lifestyle on reducing the effects of stress on coronary artery disease by reviewing seven cohort studies from a European initiative that included more than 100,000 people.
Subjects were disease-free during the 15-year study period (1985-2000), ranged in age from 17 to 70 (mean 44.3) years, and resided in the United Kingdom, France, Belgium, Sweden and Finland. More than half (52 percent) were women.
Of the total participants, nearly 16,000 individuals (16 percent) reported job stress, which was determined from specific job-related questions in the studies.
The investigators defined three lifestyle categories based on smoking, alcohol consumption, physical activity/inactivity and obesity (body mass index).
A ?healthy lifestyle? had no lifestyle risk factors, ?moderately unhealthy lifestyle? had one risk factor and ?unhealthy lifestyle? included 2 to 4 lifestyle risk factors.
A total of 1,086 participants had incident events of coronary artery disease events during the followup period.
The 10-year incidence of coronary artery disease was 18.4 per 1000 people for people with job strain and 14.7 for those without job strain.
People with an unhealthy lifestyle had a significantly higher 10-year incidence rate (30.6 per 1000) compared to those with a healthy lifestyle (12.0 per 1000). The incidence rate was 31.2 per 1000 for participants with job strain and an unhealthy lifestyle but only 14.7 for those with job strain and a healthy lifestyle.
?The risk of coronary artery disease was highest among participants who reported job strain and an unhealthy lifestyle; those with job strain and a healthy lifestyle had about half the rate of this disease,? said researcher Mika Kivim?ki, Ph.D.
?These observational data suggest that a healthy lifestyle could substantially reduce the risk of coronary artery disease risk among people with job strain.?
Evidence from randomized controlled trials has shown that lifestyle changes such as weight loss and stopping smoking can reduce the risk of disease.
?In addition to stress counseling, clinicians might consider paying closer attention to lifestyle risk factors in patients who report job strain,? the authors conclude.
Source: Canadian Medical Association Journal
Stethoscope shaped as a person photo by shutterstock.
APA Reference
Nauert PhD, R. (2013). Work Stress, Unhealthy Lifestyle Impact Coronary Arteries. Psych Central. Retrieved on May 20, 2013, from http://psychcentral.com/news/2013/05/20/work-stress-unhealthy-lifestyle-impact-coronary-arteries/55063.html
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Greece is rolling out the red carpet for Chinese investors as a means of stabilizing its shaky economy.
China's Premier Li Keqiang (r.) and Greece's Prime Minister Antonis Samaras talk during a signing ceremony at the Great Hall of the People in Beijing last week. Mr. Samaras is hoping to convince the Chinese to invest in Greece, which could help ease the country's debt crisis.
Jason Lee/Reuters
EnlargeOfficials in Brussels and Washington may view China?s global shopping spree with alarm, as the Asian power house continues to buy up companies, sovereign debt, ports, and bridges around the world. But the Greeks are already dusting off the red carpet.
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On a five-day visit to Beijing that ended Monday, Greek Prime Minister Antonis Samaras eagerly invited the Chinese to "join Greece's success story," hoping to lure the country?s ravenous investors to Greece and pump new life into the country's devastated economy.
After global rating agency Fitch upgraded Greece's sovereign credit rating from CCC to B- last week, Mr. Samaras tried to convince Chinese officials that the economic crisis plaguing Greece would soon come to an end.
"I wouldn't be here if we in Greece hadn't turned our ship around," he told them during his visit, flanked by 71 Greek businessmen and members of his cabinet, who had to pay their own way to Asia because of budget austerity measures.
After six years in recession, the unemployment rate in Greece has reached 27 percent, and 64 percent for those under the age of 25. In the first quarter of this year, the economy contracted 5.3 percent, the fifth consecutive year of negative growth.
Hoping to turn things around, Greece signed an agreement with its creditors, which hold billions in Greek debt, to raise $67 billion by 2022 by selling off state assets. And the Chinese have already expressed interest in Athens International Airport, along with some of Greece?s 12 ports for lease.
"There's a strong interest from China for infrastructure investments in Greece, especially in ports and railways," says Nicholas Economides, professor of economics at the Stern School of Business at New York University. "Greece will benefit from the efficient running of its infrastructure [brought on by the sale], as well as investment in its infrastructure once those are privatized."
Officials in particular are hoping to replicate the successful partnership between the Greek government and state-owned Chinese Shipping Company COSCO, which they say has revitalized the port of Piraeus and brought in millions of euros in tax revenue. The company has leased half the port since 2010 for 500 million euros in total for a period of 35 years. The Greek government now wants to lease the other half, and COSCO officials have said they are interested.
Samaras and company did not leave China empty handed. Officials from the China Development Bank promised to finance Chinese companies interested in buying Greek assets, while Chinese investors promised to soon visit the country.
And Greece is sweetening the pot for foreign investors. Earlier this month, Greek lawmakers passed a bill offering a 5-year residence permit to non-EU citizens investing in property worth more than 250,000 euros ($320,000). That would allow such investors to bring their families to Greece and at the same time, travel freely within the Schengen zone of 26 European countries.
But Greece's deals with China are not without critics.
Some worry over such arrangements with China, especially whether they would benefit the average voter. Whistleblowers at the port of Piraeus have complained publicly that COSCO has violated Greek labor laws, by underpaying them and not allowing them to form a union. Some?ex-workers have even sued the company for those violations.
Another concern is that Greek officials ? already under severe?pressure from its creditor "troika" of the International Monetary?Fund, the European Union, and the European Central Bank ? will sell?off state assets too cheaply and with few conditions, to the country's?disadvantage.
And the EU already is worried about Chinese business practices. European Union Trade Commissioner Karel De Gucht announced just last week he was preparing to launch a formal investigation into telecommunications giant Huawei whose imports into the EU are worth more than $1.3 billion for violating Europe?s competition law.
"Huawei and ZTE are dumping their products on the European market," Mr. De Gucht told Reuters, adding that access to cheap Chinese capital ?creates a distorted playing field.?
The day after Mr. De Gucht's announcement, Greek Development Minister Kostas Chatzidakis stopped Huawei's headquarters in Shanghai. The international company has agreed to build a research center and a transit hub in Greece, according to the Greek Ministry of Development.
And during his visit, Samaras shied away from bringing up the usual human rights issues most of his Western counterparts make a point to address while visiting Beijing.
Instead, Samaras kept the talks focused on business opportunities, and used the rich ancient past of both nations as a key reason why China should help Greece.
"If the two countries with the greatest legacies in the world do not combine forces to create such synergies???if we do not do it, nobody else can," Samaras told Chinese officials.
But nostalgia aside, China is firmly rooted in the economic considerations of the present that has led it to become a leading exporter and economic powerhouse, analysts say, scoffing at the hope that Chinese investment could be a panacea for Greek economic woes.
"We shouldn't consider them as a deus ex machina,?? says Charalambos Paposotiriou, professor of international relations at Panteion University in Athens and author of a recent book about China's rise as a superpower. ?They might help with our recovery but we should also become more competitive."
Another recent deal underscores the competition: Greece, which used to be one of the leading builder of ships until the '90s, saw its shipping magnates recently agree to buy 142 new ships from Chinese shipbuilders.?
"There might be mutual respect between the Chinese and the Greeks because they're both ancient civilizations,? adds Mr. Paposotiriou. ?But people shouldn't forget that China operates according to its interests and profits."
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May 21, 2013 ? Imagine a pharmaceutical prevention, treatment or even cure for Alzheimer's disease.
It is almost impossible to overstate how monumental a development that would be and how it would answer the prayers of millions.
Though science isn't there yet, a new study published in The Journal of Neuroscience spearheaded by USC Davis School of Gerontology researchers offers a tantalizing glimpse of potential solutions.
"Our data suggests the possibility of drugs that can prevent and treat Alzheimer's," said lead author, professor and lab principal Christian Pike of USC Davis. "It's just mouse data but extremely encouraging mouse data."
The team studied the effects of a class of drugs called TSPO ligands on male mice that were genetically engineered to develop Alzheimer's disease, known as 3xTg-AD mice. Because a key mechanism of TSPO ligands is to increase production of steroid hormones, it was important to ensure that the mice had low levels of testosterone and related hormones before treatment. Younger mice were castrated while, in older mice, the decrease occurred as a normal consequence of aging.
"We looked at the effects of TSPO ligands in young adult mice when pathology was at an early stage and in aged mice when pathology was quite severe," Pike said. "TSPO ligands reduced measures of pathology and improved behavior at both ages."
The most surprising finding for Pike and his team was the effect of TSPO ligands in the aged mice. Four treatments -- one per week over four weeks -- in aged 3xTg-AD mice resulted in significant lowering of Alzheimer's-related pathology and improvements in memory behavior. This finding suggested the possibility that TSPO ligands can reverse components of Alzheimer's and thus have the potential to be useful in treatment.
For humans, these findings may indeed be quite significant.
"TSPO ligands are currently used in humans in certain types of neuroimaging. Newer TSPO ligands are at the clinical trials stage of development for treatment of anxiety and other conditions," Pike said. "There is a strong possibility that TSPO ligands similar to the ones used in our study could be evaluated for therapeutic efficacy in Alzheimer's patients within the next few years."
In light of the findings, the team will next focus on understanding how TSPO ligands reduce Alzheimer's pathology. Building on the established knowledge that TSPO ligands can act protectively by reducing inflammation, shielding nerve cells from injury and increasing the production of neuroactive hormones in the brain, the team will study which of these actions is the most significant in fighting Alzheimer's so it can develop newer TSPO ligands accordingly.
While Pike and his team acknowledged that the findings represent an exciting possibility, the researchers also stressed that it is by no means a given.
"From the optimistic perspective, our data provide very promising findings with tangible potential benefits for both the prevention and treatment of Alzheimer's," Pike said. "On the pessimistic side, research scientists have developed many interventions that cured Alzheimer's in mice but have failed to show significant benefits in humans. A critical direction we are currently pursuing is successfully translating these findings into humans."
Co-authors of the study were Anna Barron (former USC Davis postdoctoral student and Molecular Imaging Center, National Institute of Radiological Sciences, Japan); Luis Garcia Segura (Instituto Cajal, Spain); Donatella Caruso and Roberto Melcangi (Department of Pharmacological and Biomolecular Sciences, Centre of Excellence on Neurodegenerative Diseases, University of Milan); and Anusha Jayaraman and Joo Lee (USC Davis).
The research was funded by the National Institutes of Health in support of the USC Alzheimer's Disease Research Center, directed by Helena Chui, professor of neurology and gerontology at USC.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/4qlBDWU1pHs/130521153940.htm
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